http://www.weillcornell.org/neuphyslab/
http://www.neurosurgery.pitt.edu/clinical_neurophysiology/index.html
http://www.muschealth.com/neurosciences/about/neurophysiologylab/services/iom.html
http://www.hopkinsmedicine.org/neurology_neurosurgery/specialty_areas/ionm/
http://epilepsie.hug-ge.ch/moyens/Neurophys_Neuromod_Enx.pdf
more to be placed..!
The discovery of a cure for MS will not be attributable to a single medical breakthrough but a series of medical discoveries and innovations leading to the cure. This process will involve biochemists and vascular researchers; physicists and radiologists; engineers and neurosurgeons, immunologists and geneticists among many other scientific disciplines. This is not to discard the new theory of a vascular disease connection. But that is only the snowball that got the avalanche moving down the slope. The theory that a simple dilation of the jugular veins can achieve a cure for MS oversimplifies the explanation of the disease pathways and ultimately obscures therapeutic objectives. Since it was proposed three years ago, it has also politicized a specific disease like never before.
ReplyDeleteAnyone looking at the empirical evidence demonstrated by the growing number of MS patients who are commonly affected once the retrograde blood flow pressure on the brain is relieved by expanding the occluded jugular veins will quickly agree that Zamboni’s hypothesis is more or less correct; that an equalization of the outflow of blood from the CNS to the heart muscle is essential to reducing the presenting symptoms of MS. But the surgical act of neck vein dilation by itself will not come close to providing the cure. Once the vascular pressures are balanced, only a correlation between a vascular event and the disease itself has been demonstrated. The occluded neck veins do not explain the autoimmune trigger that causes the disease.
Connecting those dots via the clinical findings from the effect of autologous cells transplanted to the MS brain goes a long way toward the explanation, but again does not identify the trigger. In individuals predisposed to MS, whatever prompts the autoimmune response, inevitable and irreparable damage to the myelin and the interlaced axonal matrix occurs through the pattern of the disease. In multiple clinical trials, suppression of the disease event cascade has been demonstrated with the introduction of Mesenchymal stromal cells (MSCs) to the diseased CNS. Once these cells are introduced, the resultant biochemical event sequence has been observed, biochemically identified, measured and described in several important trials. Where the retrograde pressures caused by the stenotic vessels reflux and deposit deoxygenated and iron-rich hemoglobin on the myelin covering of the CNS, MSCs respond by inducing suppression of various immune cell populations and inhibit white blood cells from evaluating the sites of insult and erythrocyte extravasations. But it’s still not known why only some people get MS since the same diseased pathology and internal biochemical conditions exist in human populations that never exhibit the autoimmune response.For more information please visit http://www.ccsviclinic.ca/?p=952